Chicagoland Peptides

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BPC-157

Last reviewed: September 15, 2026

Selected peer-reviewed reports on the pentadecapeptide BPC-157 are summarised below. Each finding is labelled with the experimental model in which it was obtained. Preclinical results are not presented as human clinical results. In a 1993 overview, investigators described isolation of a gastric-juice peptide named BPC and characterization of a 15-amino-acid fragment designated BPC 157, and they reviewed subsequent work in animal models of tissue lesions.[1] In rats with a surgically transected Achilles tendon (animal), investigators reported higher load-to-failure and related biomechanical measures, higher Achilles functional index values, and smaller tendon defects after BPC 157 than after saline.[2] In cultured tendocytes from that programme (in vitro), BPC 157 was reported to oppose growth inhibition by 4-hydroxynonenal without itself increasing growth of the cultured cells.[2] In tendon explants and cultured fibroblasts derived from rat Achilles tendon (in vitro), BPC 157 was reported to accelerate fibroblast outgrowth from explants, to leave MTT proliferation unchanged, to increase survival under hydrogen peroxide stress, and to increase fibroblast migration.[3] In an alkali-burn skin-injury model in rats (animal), topical BPC 157 was reported to accelerate wound closure relative to the model control, with histological differences in granulation tissue, re-epithelialization, and collagen deposition.[4] In cultured human umbilical vein endothelial cells (in vitro), the same study reported increased proliferation, migration, and vascular tube formation.[4] In a rat model of ischemic colitis with ischemia and reperfusion (animal), a BPC 157 bath applied to the blood-deprived colon segment was reported to increase vessel presentation and preserve mucosal folds, and colon malondialdehyde and nitric oxide measurements in BPC 157-exposed tissue were reported as normalised relative to the untreated ischemic comparators in that study.[5] In isolated human internal mammary artery rings obtained during coronary artery bypass operations (human tissue, organ-bath assay), BPC 157 produced a concentration-dependent reduction of phenylephrine-induced contraction that was greater in endothelium-intact rings than in endothelium-denuded rings, and nitric-oxide synthase inhibition with L-NAME attenuated that relaxation.[6]

In plain terms

A 1993 overview described isolation of a stomach-juice peptide called BPC and a 15-amino-acid fragment called BPC 157, and reviewed later work in animal models of tissue lesions.[1] In rats with a surgically cut Achilles tendon (in animals), investigators reported higher load-to-failure and related strength measures, higher Achilles functional index values, and smaller tendon gaps after BPC 157 than after saline; in cultured tendon cells from that programme (cells in a lab), BPC 157 was reported to oppose growth inhibition by a stress chemical without itself increasing growth of those cultured cells.[2] In tendon pieces and cultured fibroblasts from rat Achilles tendon (cells in a lab), BPC 157 was reported to accelerate fibroblast outgrowth from explants, leave a standard proliferation read unchanged, increase survival under hydrogen peroxide stress, and increase fibroblast migration.[3] In rats with an alkali-burn skin injury (in animals), topical BPC 157 was reported to accelerate wound closure relative to the model control, with histological differences in granulation tissue, re-epithelialization, and collagen deposition.[4] In cultured human umbilical vein endothelial cells (cells in a lab), the same study reported increased proliferation, migration, and vascular tube formation.[4] In rats with ischemic colitis (blood flow cut then restored; in animals), a BPC 157 bath on the blood-deprived colon segment was reported to increase vessel presentation and preserve mucosal folds, and some tissue chemistry measures in BPC 157-exposed tissue were reported as normalised relative to untreated ischemic comparators in that study.[5] In rings of human internal mammary artery obtained during coronary bypass operations and studied in an organ bath (human tissue, not a clinical treatment trial in people), BPC 157 produced a concentration-dependent reduction of phenylephrine-induced contraction that was greater when the endothelium was intact than when it was removed, and nitric-oxide synthase inhibition with L-NAME attenuated that relaxation.[6]

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Lab reports

References

  1. Sikirić P, Petek M, Rucman R, Seiwerth S, Grabarević Z, et al.. A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.. Journal of physiology, Paris. 1993. (animal) PubMed
  2. Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, et al.. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2003. (animal) PubMed
  3. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.. Journal of applied physiology (Bethesda, Md. : 1985). 2011. (in vitro) PubMed
  4. Huang T, Zhang K, Sun L, Xue X, Zhang C, et al.. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro.. Drug design, development and therapy. 2015. (animal) PubMed
  5. Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, et al.. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights.. World journal of gastroenterology. 2017. (animal) PubMed
  6. Yildirim AK, Dastan AO, Demeli Ertus M, Ensarioglu M, Karabacak K, Pehlivanoglu B. Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery.. Journal of clinical medicine. 2026. (human) PubMed